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EUROIMMUN provides reliable, state-of-the art in vitro test systems for the determination of specific IgE antibodies in patient sera With “ CCD band ” as an additional indicator for the clinical relevance of Specific IgE results.
In the EUROLINE test system membrane strips with 20 different allergens are used, allowing a detailed patient allergy profile to be obtained with a single test. Moreover, the specific antibodies are determined semi quantitatively by comparing the intensities with the help of “ Euroline Scan System ” |
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Profiles Available...
1. Euroline India Specific Food Profile
2. Euroline India Specific Inhalation Profile
3. Euroline Allergy Profile Atopy
4. Euroline Allergy Profile Pediatrics
5. Euroline Allergy Profile Insect Venoms
Key Features
 Separate Membrane strip for each sample
Highly pure antigens: No cross-reaction
Easy and reliable differentiation between positive and negative samples
Intensity of the antigen bands correlate with the antibody titer
Automated semi-quantitative evaluation with EUROLineScan
Classification of results in RAST/EAST system
Excellent correlation with the Phadia CAP system
Small sample volumes (only 100 µl), ideally suited for Paediatrics
Detection of specific IgE antibodies against Cross-reactive Carbohydrate Determinants (CCD) on India specific Food and Inhalation profiles.
Fast test performance – approx. 2.5 hours with only 100 µl sample
India Specific Food
Milk
Hen eggs yolk
Milkpowder
Wheat Flour
Rice
Soyabean
Peanuts
Coconut
Apple
Grape
Potato
Spinach
Onion
Cucumber
Chicken
Mustard
Coffee
Ginger
Shrimp
Prawn
CCD
Indicator
India Specific Inhalation
Timothy grass
Rye cultivated
Corn
Eucalyptus sp.
Parthenium hysterophorus
Carnation flower
Sunflower seeds
Mites(D1 & D2)
Dermatophagoides farinae
Cockroach
Cat epithelium
Dog hair
Pigeon feathers
Chicken feathers
Aspergillus fumigatus
Tricophyton Mentagrophytes
Cotton yarn and fabric
Straw dust
Jute
Sheeps wool
CCD
Indicator
CCD
Many allergens are Glycoproteins containing oligosaccharide side chains which are bound to the protein framework of these allergens. In some cases, patients develop specific antibodies against these carbohydrate structures. The abbreviation CCD stands for “Cross-reactive Carbohydrate Determinant”. CCDs can be found in a large number of allergens of vegetable or animal origin. Due to their significant similarity in structure, CCDs are known to cause a strong cross reactivity.
Although the importance of specific IgE antibodies against CCDs has not yet been fully understood, they are considered to be irrelevant for diagnosis in most cases and as such complicate the interpretation of positive in vitro diagnostic results. For this reason, the presence of specific IgE antibodies against CCDs may provide useful additional information, especially with positive IgE results that disagree with the clinical picture, and can serve as an interpretation aid in the evaluation of overall test results. The determination of specific IgE antibodies against CCDs can be useful in the following cases:
Clinical symptoms disagreeing with the specific IgE result obtained (e.g. in positive serological results for peanuts)
In many positive specific IgE results for plant foods
Sensitization of persons suffering from pollen allergies to CCD-rich latex without work-related exposition
Detection of specific IgE antibodies against honey bee or wasp venom without clinical symptoms
EUROLINE SCAN
The Programme EUROLine Scan has been developed by EUROIMMUN to allow fully automated, quantitative evaluation of membrane-based test systems, to facilitate administration of extensive individual data and to provide detailed documentation of results.
The incubated membrane strips are scanned onto a protocol sheet using a flatbed scanner. EURO Line Scan recognizes the position of the strips, even if they have been laid inexactly. It then identifies the bands, measures their intensity and automatically converts them into EAST (Enzyme Allergo Sorbent Test) classes, which correlate to the concentrations given in the well-known RAST (Radio Allergo Sorbent Test) system. The computer-based evaluation can be monitored and the data modified manually, whereby all changes are automatically documented. The results are then saved together with the image data. It is no longer necessary to archive incubated test strips. A separate result sheet can be produced for each patient. |
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Clinical Chemistry
